ISTU 2009 - Aix en Provence

08:00

08:24

Opening Ceremony

Session 1: Ultrasound Surgery
Chairpersons: F. Wu & J. Souquet

Invited Lecture
08:24    Global clinical vision of the role of HIFU, F. Wu
08:48    Optimal Transthoracic Targeting of Liver Tumors Using Dual-mode Ultrasound Arrays: A numerical and experimental study, A. Casper
09:00    Segmental liver resection assisted by HIFU: tissue precauterization using a toroïdal-shaped HIFU transducer, WA. N'Djin
09:12    Efficacy and safety of focused ultrasound ablation for small hepatocellular carcinoma, H. Fukuda
09:24    MR guided Focused Ultrasound Surgery for Early Breast Cancer, H. Furusawa
09:36    Can Extracorporeal HIFU Adequately Ablate Small Renal Tumours?, R. Ritchie
09:48    Preliminary results: MR guided volumetric HIFU ablation of uterine fibroids with binary feedback control, J. Enholm
10:00    Focused ultrasound to move kidney stones, MR. Bailey
10:12    Histotripsy for Pediatric Cardiac Applications: In Vivo Piglet Model, R. Miller

Session 2A: Sonothrombolysis
Chairpersons: S. Maiers & K. Hynynen

Invited Lecture
10:48    Sonothrombolysis, S. Maiers
11:12    Acoustic fields involved in clinical trials of sonothrombolysis: investigation of the TRUMBI device, JF. Aubry
11:24    An Investigation of the Use of Pulsed High Intensity Focused Ultrasound for Thrombolysis, D. Goertz
11:36    Enhancement of purely ultrasound thrombolysis efficiency using a bifrequency excitation, I. Saletes
11:48    The Effects of Microbubble Size, Physical Properties, and Acoustical Properties on the Efficacy of Microbubble-Ultrasound Mediated Sonothrombolysis, MJ. Borrelli
12:00    Transcranial Clot Lysis Using High Intensity Focused Ultrasound, T. Hoelscher
12:12    Penetration and diffusion of tissue plasminogen activator into whole blood clots following pulsed-high intensity focused ultrasound exposures, G. Jones

Session 2B: HIFU Tissue Erosion
Chairperson: M. Tanter

10:48    Feasibility of HIFU tissue ablation in the presence of ribs using a 2D random phased array, S. Bobkova
11:00    A tissue phantom for evaluation of mechanical damage caused by cavitation, A. Maxwell
11:12    Tissue erosion using shock wave heating and millisecond boiling in high intensity focused ultrasound fields, M. Canney
11:24    Tissue ablation using cavitating bubbles triggered by high intensity ultrasound pulse, S. Yoshizawa
11:36    Why Are Short Pulses More Efficient in Tissue Erosion Using Pulsed Cavitational Ultrasound (Histotripsy)?, TY. Wang
11:48    Evaluation of the contrast between tissues in rabbit in vivo and thermal lesions produced by HIFU using fast spin echo MRI sequences, C. Damianou
12:00    Adaptive volumetric MR-guided high-intensity focused ultrasound ablations in moving organs, S. He

Session 3A: Ultrasound-guided HIFU
Chairpersons: G. ter Haar & E. Ebbini*

Invited Lecture
13:36    Ultrasound guided HIFU: strength and weakness, G. ter Haar
14:00    Validating Ultrasound-based HIFU Lesion-size Monitoring Technique with MR Thermometry and Histology, S. Zhou
14:12    Real-time Two-Dimensional Temperature Imaging Using Ultrasound, D. Liu
14:24    Ultrasound-based mapping of elasticity and temperature during HIFU therapy: an ex vivo feasibility study, E. Sapin
14:36    Monitoring high intensity focused ultrasound therapy with backscattered ultrasound with a parametric treatment model, G. Speyer
14:48    Monitoring of thermal ablation during HIFU exposure using passive cavitation mapping, M. Gyöngy
15:00    HIFU Induced Displacement Estimation (HIDE) maps for monitoring the creation of thermal lesions, C. Haw
15:12    Real time motion correction for transcostal liver therapy: in vitro experiments, F. Marquet
15:24    An Automated Dosing Method for a HIFU Device Containing Multiple Phased Arrays, X. Zeng
15:36    Ultrasound-based Monitoring Technique to Control Lesion Size During HIFU Therapy, A. Anand
15:48    Ultrasound guided high intensity focused ultrasound (US-gFUS) therapy for uterine fibroids. Initial experiece in our center, J. Insern Quitllet

Session 3B: Contrast Physics & Drug Delivery
Chairperson: M. Bailey*

13:36    Development of a cannulated vessel model for the study of cell sonoporation in the presence of contrast agents, A. Tokarczyk
13:48    Validation of an acoustic Cavitation Dose in pulsed mode by the terephthalate dosimeter for in vitro drug delivery application, L. Somaglino
14:00    Cavitation-Enhanced Momentum Transfer for Drug Delivery, B. Rifai
14:12    Correlation of ultrasound-mediated drug delivery with acoustical properties of the transducer by macroscopic fluorescence imaging, M. Lepetit-Coiffe
14:24    Ultrasound-inducible fluorescent particles for internal tattooing, O. Couture
14:36    Real-time monitoring of drug delivery with MRgHIFU and image-able low temperature sensitive liposomes, A. Partanen
14:48    Ultrasonic Activation of Thermally Sensitive Liposomes, E. Mylonopoulou

Session 4A: HIFU Surgery in the Brain
Chairpersons: N. Kassel & M. Fink*

Invited Lectures
16:36    Future Clinical Role of HIFU in the Brain and the Mission of the Focused Ultrasound Surgery Foundation, N. Kassel
17:00    Experience in brain tissue necrosis using laser, A. Carpentier
17:24    MR-guided ultrasonic brain therapy: high frequency approach, JF. Aubry
17:36    Nonlinear ultrasound propagation through the skull, G. Pinton
17:48    Large–Scale Analysis of Focused Ultrasound in Heterogeneous Media, J. Uebayashi
18:00    Transcranial MR-guided High Intensity Focused Ultrasound for Non-Invasive Functional Neurosurgery, B. Werner
18:12    MR guidance, monitoring and control of Brain HIFU therapy in small animals: In vivo demonstration in rats at 7T, B. Larrat
18:24    Real-Time Magnetic Resonance Temperature Mapping in the Brain, A. Kickhefel

Session 4B: Principles of HIFU-mediated Drug Delivery
Chairperson: L. Crum

16:36    Enhancement of antitumor effect by the combination of therapeutic ultrasound and immunotherapy, N. Nishiie
16:48    Sonoporation of cervical carcinoma cells affected with E6-oncoprotein for the treatment of uterine cancer, L. Curiel
17:00    Sonoporation outcome correlated with time-resolved measurements of microbubble dynamics, Z. Fan
17:12    Short-duration focused ultrasound stimulation of Hsp70 expression in vivo, D. Kruse
17:24    Ultrasound-enhanced nanotherapy of pancreatic cancer, N. Rapoport
17:36    Cancer gene therapy by the combination of liposomal bubbles and ultrasound, R. Suzuki
17:48    Investigations in to the Influence of Pulsed High Intensity Focused Ultrasound on Metastasis in a Murine Model, H. Hancock
18:00    Pulsed-HIFU enhanced delivery and therapy using radiolabeled monoclonal antibodies, F. Razjouyan
18:12    Therapeutic benefits of ultrasound delivery of anti-Aβ antibody in an Alzheimer’s mouse model, J. Jordao
18:24    Virus-loaded microbubbles as a tool for targeted gene delivery, B. Geers

08:00

Session 5: High Intensity Focused Ultrasound Physics
Chairpersons: W. O'Brien* & C. Diederich

Invited Lecture
08:00    HIFU dosimetry, W. O'Brien
08:24    Non invasive transcostal focusing based on the decomposition of the time reversal operator: in vitro validation, E. Cohard
08:36    An analytical comparison of the thermal dose equation and the intensity-time product, It^m, for predicting tissue damage thresholds, G. Harris
08:48    Energy Based Adaptive Focusing: Optimal Ultrasonic Focusing using Radiation Force MR Guidance, B. Larrat
09:00    The effect of electronically steering a phased-array transducer on proximal tissue heating, A. Payne
09:12    On the mathematical model of ultrasound propagation in liver, G. Vilenskiy
09:24    The effect of visco-elasticity on the stability of inertial cavitation, D. Sinden
09:36    Perfusion models for steep thermal gradients, S. Woodford
09:48    Fast ultrasound beam simulation in inhomogeneous tissue geometries for MRI-guided HIFU, U. Vyas
10:00    HIFU Thermometry and Acoustic Calibration Using a Fibre-optic Hydrophone, J. Civale

Session 6A: Use of Cavitation in HIFU
Chairpersons: L. Crum & C. Coussios

Invited Lecture
10:48    Cavitation during HIFU treatment, L. Crum
11:12    Characterization of HIFU-induced cavitation activity and heating in porcine subcutaneous fat, ZM. Kyriakou
11:24    On cellular response to low intensity ultrasound, N. Mizrahi
11:36    Analysis of the microbubble dynamics under the ultrasound exposure, Y. Nakamura
11:48    A Real-Time Controller for Sustaining Thermally Relevant Cavitation during HIFU exposure, N. Hockham
12:00    Characterization of Perfluorocarbon Droplets for Focused Ultrasound Therapy, K. Schad
12:12    Temperature distribution heating experiment using HIFU and microbubble, H. Utashiro
12:24    Modelling oscillations of a microbubble in an elastic vessel, S. Martynov

Session 6B: Efficacy of HIFU-mediated Drug Delivery
Chairperson: B. Wood

10:48    In vivo and ex vivo assessment of pulsed HIFU-enhanced penetration of small molecules, JH. Hwang
11:00    Closed-loop controlled noninvasive ultrasonic glucose sensing and insulin delivery, N. Smith
11:12    Ultrasonic drug delivery in phase-shift nanoemulsions, N. Rapoport
11:24    Enhancement of doxorubicin effect on cancer cell mortality with ultrasound and microbubbles, J. Piron
11:36    Qualitative and quantitative evaluation of nanoparticles delivery into tumor tissue enhanced by focused ultrasound with microbubbles, CY. Lin
11:48    Controlled ultrasound-induced delivery of doxorubicin from liposomes on AT2-Dunning tumors: Preliminary studies, C. Lafon
12:00    Inertial cavitation enhances the extravasation and therapy of an oncolytic adenovirus for breast cancer treatment, M. Bazan-Peregrino 

Session 7A: Use of Cavitation in HIFU
Chairpersons: G. Harris & G. ter Haar

Invited Lecture
13:36    HIFU and Regulatory Challenges, G. Harris
14:00    Realtime acousto-optical QA methods for high intensity fields, I. Butterworth
14:12    Effects of thermal dose-dependent absorption on temperature rise and lesion volume in HITU applications, J. Soneson
14:24    Spatially and temporally-controlled mild hyperthermia using a linear array, CY. Lai
14:36    Contrast agent ultrasonography before and after HIFU treatment of parathyroid glands, F. Lacoste
14:48    Tumor-specific immune response induced by HIFU therapy: a study in a mouse model, T. Khokhlova

Session 7B: Drug Delivery and Monitoring in the Brain
Chairperson: E. Konofagou

13:36    Mechanism and safety at the threshold of BBB opening in vivo, E. Konofagou
13:48    Focused ultrasound induced blood-brain barrier to enhance chemotherapeutic drugs (BCNU) delivery for glioblastoma treatment, HL. Liu
14:00    Dual Photon Investigation of Ultrasound Induced BBB Disruption – A Threshold and Dynamics Study, J. Drazic
14:12    The dynamic of FUS-induced BBB Opening in Mouse Brain assessed by contrast enhanced MRI, JW. Jenne
14:24    Identifying the Inertial Cavitation Threshold of Monodispersed Microbubbles and Skull Effects in a Vessel Phantom Using Focused Ultrasound, YS. Tung
14:36    Time reversal ultrasound system for enhanced drug delivery in rat brain, L. Fillinger
14:48    A high precision MR-compatible three-axis positioning system for focused ultrasound drug delivery in small animal models, A. Waspe 

Session 8: HIFU Transducers
Chairpersons: P. Khuri-Yakub & JY. Chapelon

Invited Lecture
15:48    HIFU Transducers - a vision for the future, P. Khuri-Yakub
16:12    High power low impedance therapeutic intracavitary phased array, A. Kukic
16:24    Dual-mode 64-element array for interstitial ultrasound imaging and thermal ablation, N. Owen
16:36    Development of a new HIFU device for treating glaucoma: Preliminary results, T. Charrel
16:48    Design of a High Intensity Focused Ultrasound multi-element phased array for transcostal treatment of liver tumours, P. Gelat
17:00    Thermal ablation of liver tumors by high intensity focused ultrasound using a toroid transducer. Results of Animal Experiments, D. Melodelima
17:12    Effects of respiratory motion on in-vivo HIFU treatments: a comparative study in the liver, WA. N'Djin
17:24    Criteria for modelling the capabilities of a 48 element phased array HIFU transducer, I. Rivens
17:36    Direct methods for free field characterization of HIFU transducers using acoustic streaming, P. Hariharan
17:48    Measurement of the total acoustic output power of HITU transducers, KV. Jenderka
18:00    Feasibility of a PVDF Receiver for Monitoring of Transcranial Therapy, M. O'Reilly 

Session 9: HIFU in the Prostate
Chairpersons: M. Emberton & E. Blanc

Invited Lecture
08:00    HIFU of the prostate: its challenges, its strength and weakness, M. Emberton
08:24    Primary prostate HIFU: Local control and Biochemical survival of 966 patients tracked with the @-registry, A. Gelet
08:36    Ten-year biochemical disease-free survival after high intensity focused ultrasound (HIFU) for localized prostate cancer: a comparison of 3 different…, T. Uchida
08:48    Analysis of acoustic access to the prostate through the abdomen and perineum for extracorporeal ablation, T. Hall
09:00    Histological Evaluation of Conformal 3D MRI-Guided Transurethral Ultrasound Therapy in the Prostate    S. Vedula
09:12    Ultrasound-Activated Microbubble Enhancement of Radiation Response, G. Czarnota
09:24    Ultrasound Properties of Human Tissues, L. Retat
09:36    Practical measures for evaluation of ultrasound therapies of the prostate, I. Kobelevskiy
09:48    Salvage therapy of high-intensity focused ultrasound (HIFU), S. Shoji
10:00    HIFU partial treatment of localized prostate cancer: influence on erectile dysfunction (ED), A. Gelet 

Session 9: MRI Monitoring during HIFU Procedures Chairpersons: B. Quesson & J. Ha Hwang

Invited Lecture
10:48    Rapid and volumetric MRI thermometry for monitoring HIFU ablation in the liver during breathing, B. Quesson
11:12    Real time MR for in vivo monitoring of HIFU of the liver, A. Holbrook
11:24    Three dimensional motion compensation for real-time MRI guided focused ultrasound treatment of abdominal organs, M. Ries
11:36    Inter-costal liver ablation under real-time MR-thermometry with partial activation of a HIFU phased array transducer, B. Quesson
11:48    The optical sensing and imaging of HIFU lesions, R. Roy
12:00    Rapid MR-ARFI method for focal spot localization during focused ultrasound treatments, E. Kaye
12:12    Thermal analysis of the surrounding anatomy during 3D MRI-guided transurethral ultrasound prostate therapy, M. Burtnyk
12:24    Temperature mapping near the surface of ultrasound transducers using susceptibility-compensated magnetic resonance imaging, A. Webb
12:36    Alternative focal spot geometry for more efficient HIFU treatment assessment, E. Kaye
12:48    Robotically assisted MRgFUS system, JW. Jenne